Should I take magnesium with Prilosec?

Omeprazole: Answers to 24 Common Questions About Proton Pump Inhibitors

1. What is omeprazole?

Omeprazole is a drug used to reduce the amount of acid your stomach produces. It is used to treat indigestion, acid reflux, stomach ulcers, and Zollinger-Ellison syndrome.

It is available in the form of tablets, capsules, or as a liquid. A prescription is usually required for this, but you can also buy the lowest strength (10-20 mg) in the pharmacy without a prescription.

Omeprazole is the name of the active ingredient. Many generic drugs are also sold under this name. It is sold under the trade name Antra, among other things.

2. How does omeprazole work? Is it an antacid?

Omeprazole is a proton pump inhibitor or proton pump inhibitor (PPI). This means that it works by blocking the enzymes that pump acid into the stomach.

It's not an antacid - antacids work by neutralizing stomach acid after it's been produced. PPIs prevent stomach acid from getting into the stomach in the first place.

3. What is the difference between omeprazole and ranitidine?

Omeprazole and ranitidine are both used to reduce the amount of acid made by the stomach. However, they work in different ways.

Ranitidine (usually sold under the brand name Zantac, but not available in Germany) belongs to an older class of drugs called histamine antagonists or H2 blockers. Histamine is a natural chemical that stimulates your stomach to produce acid, which is necessary for the digestion of food. Ranitidine and other histamine antagonists block histamine so your stomach makes less acid.

At the time of this article's publication, the EMA is reviewing drugs containing raniditin and assessing whether they should be withdrawn from the market.

Omeprazole belongs to a newer class of drugs called proton pump inhibitors (PPIs), which work by blocking the enzyme that delivers acid to the stomach.

4. Can I get omeprazole without a prescription?

You can get omeprazole in the pharmacy in the form of tablets or capsules with the lowest strength of 20 mg without a prescription. For anything stronger, you have to get a prescription from your doctor.

If you are self-treating with omeprazole (i.e. without medical advice), do not take omeprazole for more than two weeks without consulting a doctor.

5. How long does it take for omeprazole to work?

Omeprazole usually starts working after two to three days, but it may take four weeks to take full effect, so you may experience acidic symptoms for a few weeks after you start taking omeprazole.

Talk to your doctor or health care professional if you are self-treating with omeprazole and you don't feel better after two weeks.

6. When is the best time to take omeprazole?

Omeprazole should be taken in the morning 30-60 minutes before a meal.

If you take omeprazole twice a day, take it once in the morning and once in the evening.

7. Can I take omeprazole on an empty stomach? Or do I have to take it with or after a meal?

The effect of omeprazole is reduced if it is taken with food. Therefore, like any other proton pump inhibitor, omeprazole should be taken 30-60 minutes before eating. However, no side effects are to be expected from concomitant food intake.

8. I experience side effects with omeprazole. What are the options for dealing with them?

Some people taking omeprazole experience side effects while taking this drug. These side effects are usually mild and go away when you stop taking omeprazole.

Here are some common side effects and ways to deal with them:

  • Headache - rest and drink plenty of water. If you think it necessary, you can ask a pharmacist to recommend a pain reliever. Talk to your doctor or health care professional if your headache lasts for more than a week or if it gets severe.
  • Diarrhea or vomiting - make sure you drink plenty of water or use an oral rehydration solution available from a pharmacy.
  • Nausea - try to avoid rich or spicy foods.
  • stomach pain
  • Constipation - try to eat more high fiber foods, exercise, and drink plenty of water.
  • Gas - avoid foods that cause gas, such as beans and onions.
  • Dizziness - if you feel dizzy, sit down, rest, and wait for the dizziness to pass.

However, some side effects are serious and you should see a doctor right away if you notice any of the following side effects:

  • Joint pain along with a red rash, especially in areas exposed to the sun such as arms, cheeks and nose - these are possible signs of subacute cutaneous lupus erythematosus, a rare condition that can occur years after taking omeprazole
  • Yellow skin, dark urine, and tiredness - these are possible signs of liver problems
  • Blistering and peeling of the skin and / or blisters and bleeding in the eyes, nose, mouth, lips and genitals - these are possible signs of Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).
  • It is also important to be aware of the signs of an allergic reaction. If you experience an allergic reaction to omeprazole, you should see a doctor immediately.

Signs of a severe allergic reaction include:

  • Skin rash - for example, itchy, red, or swollen skin
  • Panting
  • Tightness in the chest or throat
  • Difficulty breathing or speaking
  • Swollen mouth, face, lips, tongue, or throat

A full list of all side effects can be found in the package leaflet.

9. Are there any long-term side effects from taking omeprazole?

There is an increased risk of low blood magnesium levels if you have been taking omeprazole for more than three months. Signs of magnesium deficiency include dizziness, confusion, tiredness, muscle twitching, shakiness, and an irregular heartbeat. Talk to your doctor or health care professional if you experience any of these symptoms.

There may be an increased risk of certain side effects if you have been taking omeprazole for more than a year. These include broken bones, intestinal infections, and vitamin B12-Defect. Among the signs of a vitamin B.12Deficiencies include tiredness, mouth ulcers, a sore and red tongue, and a tingling sensation. If you have been taking omeprazole for more than a year, your doctor will monitor your health for these problems.

10. I think I have overdosed on omeprazole. What should I do?

If you take too much omeprazole, signs of overdose may occur such as dizziness, tiredness, double vision, slurred speech, diarrhea, or fainting. If you get any of these symptoms you should see a doctor straight away.

11. I want to stop taking omeprazole. Will I experience withdrawal?

It is very unlikely to cause problems after short-term use.
However, if you have been taking omeprazole for a long time, you should gradually reduce your dose over time. Do not stop taking omeprazole suddenly; this can cause your stomach to produce a lot more acid. Ask your doctor for advice on how to do this.

12. Can I drink alcohol while taking omeprazole?

There is no evidence that alcohol has an additional negative effect on therapy with omeprazole. However, it is generally recommended that you drink less alcohol, as it can cause your stomach to produce more acid, which can make your symptoms worse.

13. Can I take omeprazole while pregnant?

It is usually safe to take omeprazole during pregnancy, but you should always speak to your doctor if you are thinking of taking any medication while pregnant or breastfeeding.

However, if you are pregnant, it is better to first try to treat your indigestion with methods other than medication. Talk to your doctor or health care professional for advice on how to do this. They may suggest changing your lifestyle, such as eating small meals more often, avoiding rich or spicy foods, and raising the headboard of your bed. If these methods don't work, he may recommend omeprazole or another drug.

14. Can I take omeprazole while breastfeeding?

This is something to discuss with your doctor.

Omeprazole is generally considered safe to use while breastfeeding if your baby is healthy. It only passes into breast milk in very small amounts that are unlikely to be harmful to the baby. However, you should always talk to your doctor or health care professional first about any medication you might take during pregnancy or breastfeeding. If your baby is premature or has any health problems, it is especially important to discuss with your doctor before taking any medications, including omeprazole.

15. Can I take omeprazole with an antacid?

Yes, but you must allow a two-hour break between taking omeprazole and the antacid.

16. Can I take pain relievers such as acetaminophen, ibuprofen, or naproxen while taking omeprazole?

In general, it is safe to take the active ingredients paracetamol, ibuprofen, or naproxen while taking omeprazole. However, it is best to ask a doctor or pharmacist to recommend a pain reliever that is safe for you to take.

17. Can I take omeprazole with warfarin?

Do not take omeprazole with warfarin without talking to a doctor first. The reason for this is that omeprazole can increase the levels of warfarin in your body, leading to an increased risk of bleeding. If your doctor considers it necessary for you to take omeprazole and warfarin at the same time, he or she may adjust your dose of warfarin and monitor you regularly.

18. Can I take omeprazole while taking clopidogrel?

Clopidogrel is an anti-platelet agent (blood thinner). It is a very commonly prescribed drug and is used to prevent blood clots.

If you are currently taking clopidogrel, do not take omeprazole without talking to a doctor first. The reason for this is that omeprazole can interfere with the way clopidogrel works, making it much less effective at preventing blood clots.

If you experience acidic symptoms such as indigestion or heartburn while taking clopidogrel, talk to a doctor or pharmacist for advice on what heartburn medication you can take with clopidogrel.

19. Can I take omeprazole with amphetamines such as Ritalin?

If you think you must take omeprazole with amphetamines, talk to your doctor or pharmacist first. This is because omeprazole can interact with amphetamine and affect the onset of amphetamines' effects. It is always best to check with a doctor or pharmacist if you are taking more than one medication at the same time.

20. Can I take omeprazole with citalopram?

It can be dangerous to take omeprazole with citalopram, as omeprazole can prevent the body from breaking down citalopram, resulting in an increased amount of "active" citalopram circulating in your body. This can lead to increased side effects. Talk to your doctor or health care professional if you think you need to take omeprazole while you are taking citalopram.

21. Can I take omeprazole while taking diazepam?

Diazepam is a commonly prescribed drug that relaxes muscles, relieves anxiety, and relieves spasms.

Do not take omeprazole with diazepam without first talking to a doctor. This is because omeprazole can increase the levels of diazepam in your body, which can lead to increased side effects such as drowsiness and difficulty breathing. If your doctor agrees that you need to take both omeprazole and diazepam, they may adjust your dose or monitor you more often.

22. Does omeprazole increase the risk of developing kidney disease?

Some studies have suggested that taking proton pump inhibitors (PPIs) such as omeprazole in patients who had normal kidney function before taking omeprazole may increase the risk of developing chronic kidney disease. However, research is still divided and there is insufficient evidence that PPIs actually cause kidney disease. It is also not known whether omeprazole can worsen existing kidney disease. Talk to your doctor if you have any concerns about how omeprazole can affect your health.

23. Does omeprazole increase the risk of developing liver disease?

Some studies have suggested a link between taking proton pump inhibitors (PPIs) like omeprazole and developing chronic liver disease. However, it is rare to experience liver problems as a side effect of taking omeprazole.

Talk to your doctor or health care professional if you have liver problems before taking omeprazole, or if you get symptoms of liver disease such as yellow skin, dark urine, and tiredness while taking omeprazole.

24. Does omeprazole increase the risk of developing dementia or Alzheimer's disease?

It's not clear whether taking proton pump inhibitors (PPIs) like omeprazole can increase your risk of developing dementia or Alzheimer's disease. There is some limited evidence that there might be a link between PPIs and these disorders.


We hope the information in this article is helpful and ask that you view it as such. This article is not a substitute for professional medical advice. If you have any concerns about your medication, be sure to talk to your doctor or pharmacist. This is especially important if you are taking multiple medications or have existing risk factors or intolerances.

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