What causes chondrial sarcoma

Chondrosarcoma

1 definition

Under a Chondrosarcoma one understands a malignant bone tumor, which can arise primarily and secondarily and emerges from the cartilage tissue.

2 epidemiology

Chondrosarcoma accounts for about ten to twenty percent of all malignant primary bone tumors, with women being affected less than men.

3 etiopathogenesis

It is assumed that chondrosarcoma develops primarily in two thirds of cases and secondary in one third of cases as part of the degeneration of osteochondromas or enchondromas.

4 localization

The chondrosarcoma is often localized on the proximal humerus, the scapula, and the proximal and distal femurs.

One differentiates between a central, a periosteal and a mesenchymal chondrosarcoma.

5 clinic

In the early stages, chondrosarcoma does not cause any symptoms. There is pain later.

6 imaging

The x-ray shows an osteolytic tumor with central calcification. Computed tomography, magnetic resonance imaging and skeletal scintigraphy are also performed.

7 Differential Diagnostic

Bone metastases, the enchondroma and other cartilaginous tumors should be considered in the differential diagnosis.

8 therapy

The chondrosarcoma is largely radiation and chemoresistant, which is why an en bloc resection with generous clearance is recommended in the early stages. However, this assumes that the surrounding soft tissue is not also affected. In the event of a breakthrough with soft tissue involvement, the only last option is disarticulation.[1]

9 forecast

With an R0 resection, the 5-year survival rate for high-grade tumors is thirty percent and for low-grade tumors ninety percent. If a relapse occurs, the prognosis is poor.

10 sources

  1. ↑ Schütte et al. Guideline Malignant Bone Tumors in Adults. As of May 2011; called on 07/06/2016