What are liver fibrosis biomarkers

Automated blood test for liver fibrosis

January 31, 2012

Siemens offers the first rapid, automated biomarker test for diagnosing and assessing liver fibrosis. The ELF test (Enhanced Liver Fibrosis Test) takes around an hour. All he needs is a blood sample.

The new test was developed by Siemens Healthcare together with University College London and can be used as a routine test on the Siemens ADVIA Centaur immunoassay systems.

With the automated ADVIA Centaur ELF test, both the severity and the risk of further progression of liver fibrosis can now be detected quickly and gently. He investigates three direct blood serum biomarkers: hyaluronic acid (HA), procollagen III N-terminal propeptide (PIIINP) and the tissue inhibitor of metal proteinase 1 (TIMP-1). These direct biomarkers are molecules that are involved in the development of fibrosis. In the test, special reagents react with the biomarkers and generate light in the process. The more intense this chemiluminescence, the more biomarkers there are.

The results of the three biomarkers are converted into the ELF score using a special algorithm, which indicates the degree of fibrosis. The combination of the three biomarkers increases the accuracy of the test. As an international clinical study showed, the ELF test can precisely differentiate between minor, moderate and severe fibroses.

Press release Siemens, January 26, 2012


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Older messages

This website provides information on all aspects of liver disease. The focus is on the viral hepatitis hepatitis A, hepatitis B, hepatitis C, hepatitis D and hepatitis E, fatty liver and liver cancer. The clinical picture, diagnosis and therapy are treated. Much has changed in the treatment of hepatitis B and hepatitis C in particular. Here you will find an overview of the drugs available for hepatitis B and C, study data, specialist information and current prices. The current information from medicine and industry is aimed at those affected and doctors.