Can I take azithromycin with ciprofloxacin

Antibiotics are becoming less and less effective

Gonorrhea or gonorrhea can manifest itself as an inflammation of the urinary tract in men and as a mucous-purulent inflammation of the cervix in women. The infection is often asymptomatic, especially if the rectum or throat are affected. Undetected and therefore untreated gonorrhea can lead to inflammation of the internal female genital organs, extrauterine pregnancy and infertility. In men, inflammation of the epididymis, narrowing of the urethra and infertility are possible consequences. Children of infected women can be born with conjunctivitis and, if left untreated, go blind.

Quinolones obsolete

The WHO recommends that the choice of antibiotic for treating gonorrhea depends on the local resistance situation. Quinolones such as ciprofloxacin are clearly no longer recommended. Instead, a two-way combination of one of the third-generation cephalosporins ceftriaxone or cefixime and the macrolide azithromycin should be given. The active ingredients are administered as single doses, ceftriaxone 250 mg intramuscularly, cefixime 400 mg orally and azithromycin 1 g orally. If an antibiogram has previously shown the sensitivity of the pathogen, therapy with just one antibiotic may also be an option.

Chlamydia trachomatis infection often coexists with gonorrhea. Chlamydiosis primarily affects young, sexually active adults. In women it leads to inflammation of the cervix and in men to urinary tract infection. Infections of the rectum and the mouth and throat can also occur. Most of those affected do not notice the infection, but even in these cases it can damage the internal sexual organs and even lead to infertility. In uncomplicated genital chlamydiosis, the WHO recommends azithromycin as a single dose of 1 g or doxycycline 100 mg twice a day for seven days. Alternatively, tetracycline 500 mg four times a day, erythromycin 500 mg twice a day, or ofloxacin 200 to 400 mg twice a day, each for seven days.

The causative agent of syphilis is called Treponema pallidum. The disease is spread through contact with an infected lesion on the genitals, anus, rectum, lips, or mouth. It runs in stages that are partially asymptomatic. Another route of transmission is transplacental from the mother to an unborn child. It often leads to death or serious damage to the fetus. The WHO estimates that in 2012 there were 143,000 stillbirths, 62,000 neonatal deaths and 44,000 cases of premature birth or low birth weight due to syphilis.

Bottleneck delivery capability

According to the WHO, the first choice for the treatment of syphilis is a single intramuscular injection of 2.4 million units of benzathine penicillin G. In the case of penicillin allergy, different regimens can be used depending on the stage of the disease. In early syphilis, the alternatives mentioned are doxycycline 100 mg twice a day for 14 days, ceftriaxone 1 g intramuscularly once a day for 10 to 14 days or azithromycin as a single dose of 2 g. According to the WHO, another reason than the intolerance of the active ingredient has made benzathine therapy increasingly difficult in recent years: delivery difficulties. Non-availability has already been reported from various countries with a high prevalence of syphilis. /