Which is better BPT or engineering


Chair for Bioprocess Engineering

In the focus of the research of the Chair of Bioprocess Engineering is the development and optimization of processes for Production of biological agents, especially vaccines and recombinant proteins to be used as drugs. In addition, the Analysis of microbial communities a major role. With the help of metaproteome analysis, the composition of microbial communities is determined Biogas plants and Sewage treatment plants recorded on a structural and functional level. The information obtained is used to better understand the interactions within these communities and to increase the yield and productivity of the processes. In addition, it is examined to what extent changes in the metaproteome can be used for the early detection of process disruptions in plants. In addition to the establishment of efficient methods for protein extraction from reactor or environmental samples and the determination and analysis of the extracted proteins using high-resolution Mass spectrometry, the MetaProteomAnalyzer, a specific software for metaproteome analysis, is provided as a service for scientists and is continuously being developed at the chair within the framework of the German Bioinformatics de.NBI network.

Fig. 1: Workflow for metaproteome analysis of biogas plants.

With a view to the biotechnological processes, a holistic and system-oriented view of the biological basis and the dynamics of the respective micro and macro processes is always assumed. In addition to questions of procedural design and litigation as well as the mathematical modeling essential (partial) aspects of the examined processes, the focus is on the technical implementation and the detailed characterization of sample processes on a laboratory scale. For example, stoichiometric network models of the biogas process were validated with metaproteome data from laboratory biogas reactors.

In addition to bioprocess engineering topics, the methods of (meta-) proteome analysis established at the chair also allow processing medical issues. For example, the first analyzes of stool samples from humans show the potential for complex clinical pictures such as inflammatory bowel disease diagnose using non-invasive methods. Differences in the differentiation between different disease stages could help to control the success of therapy. In addition, the data provide important information that can contribute to a better understanding of the disease processes.

Almost all research topics are carried out in cooperation with local and international partners from science and industry. This applies in particular to the close cooperation with the Bioprocess Engineering Department of the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg.

As part of the Teaching In addition to basic subjects in the bachelor's degree in "Biosystems Technology", microbiology, bioprocess engineering and modeling of bioprocesses are offered as well as numerous supplementary and in-depth special lectures for the master's courses in the Faculty of Process and Systems Engineering. Among others: methods of protein analysis, environmental biotechnology and cell culture engineering.